Jason Mraz to make historic appearance in Myanmar

NASHVILLE, Tenn. (AP) — Jason Mraz will make history next month when he performs in Myanmar to raise awareness about human trafficking.

Mraz will headline a free outdoor concert on Dec. 16 at People's Square in Yangon, at the base of Shwedagon Pagoda.

The Grammy-winning singer-songwriter is believed to be the first international artist to perform an open-air concert in the country. The show includes local acts and is hosted by MTV EXIT, the music channel's initiative to raise awareness about human trafficking and exploitation.

"That's pretty exciting," Mraz said of the history involved, "and I'm going there with an enormous amount of gratitude and respect, and I hope we can actually make a difference. I hope it's also a testament to the songs. I've always wanted my songs to be about healing and self-empowerment, and if this is the way MTV is acknowledging that, then I am incredibly grateful."

The show, which will include local acts, will be broadcast on Myanmar national television and will air on MTV's international network in 2013. Mraz hosted a similar concert in the Philippines last year. He first became interested in the issue about four years ago when he attended the Freedom Awards, an annual salute to those working against human exploitation put on by the organization Free the Slaves.

"I thought this was something that was abolished when Abraham Lincoln signed the Emancipation Proclamation, but all it did is become hidden from our view," Mraz said in a phone interview from Zurich, Switzerland. "There was a recent estimate that there are about 27 million people enslaved on the planet, certainly due to hard economic times not just in the Western world but certainly in Third World countries. Humans as a commodity is a great way to run your business. So I signed on, lent my voice, lent my music to the cause."

Myanmar is opening itself to the world since a military junta ceded power to a new elected government last year. President Thein Sein's government has pushed the country toward democracy, and this Monday Barack Obama is scheduled to become the first sitting U.S. president to visit the country.

Mraz says there is concern predators will prey on the vulnerable in this time of great flux. The concert offers an opportunity to "educate, empower and engage." The 35-year-old singer says he plans to tailor his show to the message.

"I do curate a set list that I feel is going to be part of that educate, empower and engage (theme)," he said. "Obviously songs like 'I'm Yours,' 'I Won't Give Up' are great examples. Or '93 Million Miles' is a new one where it's about believing in yourself. And a lot of my songs are about that, about believing in yourself and really going for your dreams. Those are the kinds of songs I'll be playing at that show."

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For Alzheimer’s, Detection Advances Outpace Treatment Options

Joshua Lott for The New York Times

Awilda Jimenez got a scan for Alzheimer’s after she started forgetting things. It was positive.

When Awilda Jimenez started forgetting things last year, her husband, Edwin, felt a shiver of dread. Her mother had developed Alzheimer’s in her 50s. Could his wife, 61, have it, too?

He learned there was a new brain scan to diagnose the disease and nervously agreed to get her one, secretly hoping it would lay his fears to rest. In June, his wife became what her doctor says is the first private patient in Arizona to have the test.

“The scan was floridly positive,” said her doctor, Adam S. Fleisher, director of brain imaging at the Banner Alzheimer’s Institute in Phoenix.

The Jimenezes have struggled ever since to deal with this devastating news. They are confronting a problem of the new era of Alzheimer’s research: The ability to detect the disease has leapt far ahead of treatments. There are none that can stop or even significantly slow the inexorable progression to dementia and death.

Families like the Jimenezes, with no good options, can only ask: Should they live their lives differently, get their affairs in order, join a clinical trial of an experimental drug?

“I was hoping the scan would be negative,” Mr. Jimenez said. “When I found out it was positive, my heart sank.”

The new brain scan technology, which went on the market in June, is spreading fast. There are already more than 300 hospitals and imaging centers, located in most major metropolitan areas, that are ready to perform the scans, according to Eli Lilly, which sells the tracer used to mark plaque for the scan.

The scans show plaques in the brain — barnaclelike clumps of protein, beta amyloid — that, together with dementia, are the defining feature of Alzheimer’s disease. Those who have dementia but do not have excessive plaques do not have Alzheimer’s. It is no longer necessary to wait until the person dies and has an autopsy to learn if the brain was studded with plaques.

Many insurers, including Medicare, will not yet pay for the new scans, which cost several thousand dollars. And getting one comes with serious risks. While federal law prevents insurers and employers from discriminating based on genetic tests, it does not apply to scans. People with brain plaques can be denied long-term care insurance.

The Food and Drug Administration, worried about interpretations of the scans, has required something new: Doctors must take a test showing they can read them accurately before they begin doing them. So far, 700 doctors have qualified, according to Eli Lilly. Other kinds of diagnostic scans have no such requirement.

In another unusual feature, the F.D.A. requires that radiologists not be told anything about the patient. They are generally trained to incorporate clinical information into their interpretation of other types of scans, said Dr. R. Dwaine Rieves, director of the drug agency’s Division of Medical Imaging Products.

But in this case, clinical information may lead radiologists to inadvertently shade their reports to coincide with what doctors suspect is the underlying disease. With Alzheimer’s, Dr. Rieves said, “clinical impressions have been misleading.”

“This is a big change in the world of image interpretation,” he said.

Like some other Alzheimer’s experts, Dr. Fleisher used the amyloid scan for several years as part of a research study that led to its F.D.A. approval. Subjects were not told what the scans showed. Now, with the scan on the market, the rules have changed.

Dr. Fleisher’s first patient was Mrs. Jimenez. Her husband, the family breadwinner, had lost his job as a computer consultant when the couple moved from New York to Arizona to take care of Mrs. Jimenez’s mother. Paying several thousand dollars for a scan was out of the question. But Dr. Fleisher found a radiologist, Dr. Mantej Singh Sra of Sun Radiology, who was so eager to get into the business that he agreed to do Mrs. Jimenez’s scan free. His plan was to be the first in Arizona to do a scan, and advertise it.

After Dr. Sra did the scan, the Jimenezes returned to Dr. Fleisher to learn the result.

Dr. Fleisher, sad to see so much plaque in Mrs. Jimenez’s brain, referred her to a psychiatrist to help with anxiety and suggested she enter clinical trials of experimental drugs.

But Mr. Jimenez did not like that idea. He worried about unexpected side effects.

“Tempting as it is, where do you draw the line?” he asks. “At what point do you take a risk with a loved one?”

At Mount Sinai Medical Center in New York, Dr. Samuel E. Gandy found that his patients — mostly affluent — were unfazed by the medical center’s $3,750 price for the scan. He has been ordering at least one a week for people with symptoms ambiguous enough to suggest the possibility of brain plaques.

Most of his patients want their names kept confidential, fearing an inability to get long-term care insurance, or just wanting privacy.

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Stocks slip; Dell, Smucker drop

Stock indexes opened lower on Wall Street Friday. Dell, the personal computer maker, and J.M. Smucker, a food maker, fell after their earnings reports disappointed investors.

The Dow Jones industrial average was down 61 points at 12,480 as of 10:05 a.m. EST. The Standard & Poor's 500 index was down five points at 1,348.73. The Nasdaq composite was down 14 points 2,823.

Dell fell 65 cents to $8.90 after saying that its revenue may fall as much as 13 percent in the fourth quarter. Dell is suffering as consumers switch away from PCs to less expensive smartphones and tablets. J.M. Smucker fell $3.26 to $82.12 after its sales forecast for the company's fiscal year disappointed investors.

Investors will also watch for any developments regarding the “fiscal cliff,” as President Obama heads into budget negotiations with congressional leaders Friday.

Stocks have fallen steadily since voters returned President Barack Obama and a divided Congress to power Nov. 6, with the Dow losing 5 percent since election day. Investors are worried that U.S. leaders may not reach a deal before tax increases and government spending cuts take effect Jan. 1. The impact would total $700 billion for 2013 and could send the country back into recession.

The Dow is heading for its fourth straight weekly loss, while the S&P 500 is on track for its third losing week out of the last four.

Superstorm Sandy depressed U.S. industrial output in October, while production of machinery and equipment declined sharply, reflecting a more cautious outlook among businesses, according to a Federal Reserve report.

The Fed says industrial output fell 0.4 percent last month, after a 0.2 percent gain in September. Excluding the storm's impact, production at the nation's factories, mines and utilities would have been up about 0.6 percent.

Among other stocks making big moves:

— Gap, the San Francisco-based clothing retailer, jumped 42 cents to $33.69 after raising its revenue outlook for the year Thursday. The company also said its net income jumped in the third quarter, beating Wall Street expectations.

— Schiff Nutrition International Inc., a nutritional supplement company, jumped $9.83 to $43.75 after U.K.-based Reckitt Benckiser Group offered to pay $42 a share in cash to buy the company.

— Ruckus Wireless Inc., a maker of wireless networking equipment, dropped $1.14 to $13.89 on its first day of trading. That's a decline of 8 percent.

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Israel attack on Gaza: Familiar tension, new circumstances

JERUSALEM — Israel's surprise air assault on Gaza Strip militants killed the top military commander of Hamas and set the rivals on a familiar course that could end with another major confrontation — but in unpredictable new circumstances created by the "Arab Spring."

Compared with its past campaigns against Hamas, Israel is likely to find itself more restrained politically and militarily in the new landscape.

Rather than being able to count on former Egyptian President Hosni Mubarak to help isolate Hamas, as he did during a 22-day operation four years ago, Israel must weigh whether another large-scale Gaza offensive would endanger the landmark 1979 peace accord with Egypt, which has long served as a cornerstone of regional stability.

By Wednesday evening, Egypt's new Islamist president, Mohamed Morsi, announced he was recalling the country's ambassador to Israel to protest the assault on the Palestinian territory.

"It's a completely new game for Israel," said Yoram Meital, an Egypt expert at the Herzog Center for Middle East Studies and Diplomacy at Ben-Gurion University. "The equation before was between Israel and the Palestinians. Now it's a triangle, involving Egypt too."

Israel's offensive four years ago killed 1,200 Palestinians, but Mubarak brushed aside his own people's support for besieged Gazans and helped Israel seal Gaza's border.

The course of Israel's military campaign could be shaped by Morsi's decisions, analysts say.

Unlike his deposed predecessor, Morsi will find it difficult to ignore the anti-Israel mood of the Egyptian street. Israel is worried Egypt might open the Rafah border crossing to humanitarian aid or even Islamic fighters to help Gazans, Meital said.

"Israel is taking a very bold risk here because if this campaign continues, it could be gambling with the relationship with Egypt," he said.

Both Hamas, which has been emboldened by the new Egyptian government, and Israel, which has clashed repeatedly with it, will be watching closely to see whether Morsi comes out more strongly against Israel in the coming days or adopts a more pragmatic approach, perhaps trying to broker a cease-fire.

Besides public sentiment, Morsi must take into account his relationship with the United States and other world powers. He is seeking billions of dollars in aid and investment from the West to help the Egyptian economy. Some analysts say that even though Morsi will have to respond to be a credible Arab leader, Egyptians are more concerned with domestic problems.

Egyptian tribal leaders have blamed Hamas and other Palestinian groups for aiding the resurgence of deadly militant networks in the Sinai peninsula, who have attacked Egyptian government forces there.

Although he recalled his ambassador, Morsi did not immediately comment in public. But other leaders in the Muslim Brotherhood organization said the country would not tolerate another Israeli campaign in Gaza.

"The brutal aggression on Gaza proves that Israel has not yet learned that Egypt has changed," said Saad Katatni, head of the Muslim Brotherhood's Freedom and Justice Party.

Israeli military officials said the assault could last several days. The campaign is aimed at "defending the people of Israel who have been under rocket attack and crippling terrorist organizations' capabilities," said Israel Defense Forces spokeswoman Lt. Col. Avital Leibovitz.

Tension between Israel and Gaza militants has been mounting for nearly a week, following a missile attack against an Israeli jeep along the Gaza border that left four soldiers wounded.

In the ensuring back-and-forth violence, Hamas and other militant groups fired more than 120 rockets and mortar rounds into southern Israel, injuring several Israeli civilians and damaging property.

Israeli Prime Minister Benjamin Netanyahu has faced growing pressure to move aggressively to stop the attacks, which have terrified nearly 1 million southern Israelis and crippled daily activities.

Over the last year, Hamas, an offshoot of the Muslim Brotherhood, has resumed a more hostile stance toward Israel, betting that Morsi's election would strengthen its hand.

After observing a self-imposed cease-fire for most of the last four years, militants in recent months increased their attacks on Israel, using new types of weaponry acquired in Libya last year after the chaotic fall of Moammar Kadafi, such as antitank and antiaircraft missiles.

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2 more books coming from 'Gone Girl' author

NEW YORK (AP) — "Gone Girl" novelist Gillian Flynn is sticking around.

The million-selling author has agreed to write two more books for Random House Inc. The publisher announced Thursday that she will write a novel and a young adult novel. The books currently are untitled and publication dates have not been set.

"Gone Girl" has been among the top sellers of 2012, with sales approaching 2 million copies. Flynn's previous works include "Sharp Objects" and "Dark Places."

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Hospital Death in Ireland Renews Fight Over Abortion

DUBLIN — The death of a woman who was reportedly denied a potentially lifesaving abortion even while she was having a miscarriage has revived debate over Ireland’s almost total ban on abortions.

The woman, Savita Halappanavar, 31, a dentist who lived near Galway, was 17 weeks pregnant when she sought treatment at University Hospital Galway on Oct. 21, complaining of severe back pain.

Dr. Halappanavar was informed by senior hospital physicians that she was having a miscarriage and that her fetus had no chance of survival. However, despite repeated pleas for an abortion, she was told that it would be illegal while the fetus’s heart was still beating, her husband, Praveen Halappanavar, said.

It was not until Oct. 24 that the heartbeat ceased and the remains of the fetus were surgically removed. But Dr. Halappanavar contracted a bacterial blood disease, septicemia. She was admitted to intensive care but never recovered, dying on Oct. 28.

Mr. Halappanavar, in an interview with The Irish Times from his home in India, said his wife was told after one request, “This is a Catholic country.”

Two investigations into the case have been announced, and politicians have been quick to express their condolences and to call for legal clarity. Kathleen Lynch, a junior health minister, said medical professionals needed guidelines to deal with such circumstances.

In a statement, the hospital said it would cooperate fully with any inquest but that it had not started its own review because it wanted to consult the woman’s family first.

Mr. Halappanavar told the newspaper that he still could not believe his wife was dead. “I was with her those four days in intensive care,” he said. “They kept telling me: ‘She’s young. She’ll get over it.’ But things never changed; they only got worse. She was so full of life. She loved kids.

“It was all in their hands, and they just let her go. How can you let a young woman go to save a baby who will die anyway?”

But Mr. Halappanavar said he saw no use in being angry. “I’ve lost her,” he said. “I am talking about this because it shouldn’t happen to anyone else.”

Medical professionals were less forgiving. During a miscarriage, the cervix is opened, exposing the woman to infection, and the longer the miscarriage persists, the greater the risk, said a prominent medical commentator here, Dr. Muiris Houston. While Dr. Halappanavar’s death was “on the rare end of the spectrum,” and the facts surrounding the case are not all known, Dr. Houston said, she “undoubtedly needed to go to theater,” meaning to surgery.

“If she had gone to theater earlier she might still have died, but perhaps not,” he said. “Medicine is now increasingly driven by guidelines, and the question must be, ‘Did the hospital have protocols in place when a woman presented with such a condition?’ ”

The legal issues are, if anything, more clouded. In 1992, the Irish Supreme Court ruled that abortion was permissible in cases where there was a “real and substantial risk” to the life of a pregnant woman — including the possibility of suicide. But 20 years later, the Irish government has still not passed a law to this effect.

In 2010, the European Court of Human Rights found that Ireland was in violation of the European Convention on Human Rights by failing to provide an accessible and effective procedure to ascertain whether a woman qualified for a legal abortion.

In response, the current coalition government commissioned a report from an expert group on the issue. It was initially expected in July, but was then postponed until September — a deadline also missed. Given the divisiveness of the abortion issue in Ireland, which has prompted two bitterly fought referendums, successive governments have avoided passing any legislation.

The report was eventually delivered Tuesday night, hours before news broke of Dr. Halappanavar’s death. The government warned people not to link the two, but inevitably the death has led to calls for urgent reform.

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United Airlines has another large computer outage

Thousands of United Airlines passengers around the globe are stranded at airports and on planes after another computer outage at the world's largest carrier.

This is at least the third major computer outage for the Chicago-based airline since June.

“Does anyone have a Radio Shack computer or abacus to help United get their system fixed?,” tweeted Lewis Franck, a motorsports writer who was flying from Newark, N.J. to Miami Thursday to cover the last race of the NASCAR season.

In a subsequent phone call with The Associated Press, Franck added: “Why is there a total system failure on a beautiful day? What happened to the backup and the backup to backup?”

United Continental Holdings Inc. spokesman Charles Hobart said the airline was aware of a computer issue affecting some of its flights and was working to resolve it.

Passengers are being told by pilots and airport agents that computers are down and they don't know when the system will come back. Some fliers have been waiting nearly 2 hours to depart.

Judd Shapiro of Nashua, N.H. said he got to the gate at Logan Airport in Boston and agents told him and other frustrated fliers that planes could land but not take off.

“JetBlue is taking off, American is taking off, but United is on the ground,” he said. “I was having a flawless airport experience until I got to the gate.”

United has been struggling with technology problems since March, when it switched to a passenger information computer system that was previously used by Continental. United and Continental merged in 2010. That system, called “Shares,” has needed extensive reworking since March to make it easier for workers to use.

Michael Silverstein, who works in finance, was supposed to be on a 6:01 a.m. flight from Los Angeles to San Francisco. The computer outage had already caused him to miss one meeting and he was worried about missing another. So he walked off the plane and bought a $195 last-second ticket on a Southwest Airlines flight to Oakland, Calif.

“I'm frustrated because I'm missing a meeting that I thought I had plenty of time for,” Silverstein said.

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Pelosi decides to remain as House Democratic leader

WASHINGTON -- Nancy Pelosi, the liberal San Francisco congresswoman who became the first woman speaker of the House, will seek to remain the Democratic leader in the next Congress.

Pelosi made the announcement Wednesday to a packed meeting of her caucus.

"They say a picture is worth a million words. Well this picture is worth millions of aspirations of the American people," Pelosi told the gathering, according to a Democratic leadership aide in attendance at the closed meeting. "This new class makes our caucus historic. The first time in legislative history that a caucus will be a majority of women and minorities."

"The message is clear from the American people. They want us to work together to get things done. And that's what these folks are here to do. Just like all of you.

"We may not have the gavel, but as I can see in this room, we have the unity," Pelosi said, according to the leadership aide, who asked for anonymity to discuss the private meeting.

PHOTOS: Reactions to Obama's victory

Pelosi had been mum about her plans after Democrats failed to win the majority in Tuesday’s election.

A champion campaign fundraiser, Pelosi is regarded as a polarizing figure. Elected to the House in 1987, she was chosen by the Democratic rank and file in 2002 to succeed Richard A. Gephardt of Missouri as minority leader, becoming the first woman to head a party in either chamber of Congress, as well as the first top party leader in the House from California.

In 2007, she became speaker — and the first Californian to head the House — overseeing passage of the most far-reaching healthcare overhaul since the creation of Medicare, an economic stimulus program, and the revamping of financial regulations, often with little or no Republican support.  But while she — and her Democratic majority — ruled the House, she became a favorite Republican campaign target as evidence of what's wrong with Washington. In 2010, she ran again for minority leader after Democrats lost control of the chamber, but has stayed around in hopes of leading her party back to the majority.

Republicans welcomed the prospect of continuing to have Pelosi as a target.

"There is no better person to preside over the most liberal House Democratic Caucus in history than the woman who is solely responsible for relegating it to a prolonged minority status," said Paul Lindsay, a spokesman for the House GOP campaign arm. "This decision signals that House Democrats have absolutely no interest in regaining the trust and confidence of the American people who took the speaker’s gavel away from Nancy Pelosi in the first place."

PHOTOS: America goes to the polls

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Dave Matthews Band pledges $1M for Sandy relief

NEW YORK (AP) — The Dave Matthews Band is giving $1 million to help Superstorm Sandy recovery efforts.

The band announced Wednesday that the Nov. 30 opening show of its winter tour at the IZOD Center in East Rutherford, N.J., will be a benefit concert. All ticket and merchandise sales will go to the Bama Works Sandy Relief Fund, established at the Community Foundation of New Jersey.

Sandy's assault more than two weeks ago created widespread damage and power outages in New Jersey and New York.

The Grammy-winning group will wrap up its tour Dec. 22 in Philadelphia. Tickets are still on sale for the Nov. 30 show, which features Jimmy Cliff.

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Lance Armstrong Cuts Officials Ties With His Livestrong Charity

In the wake of being stripped of his seven Tour de France titles for doping, Lance Armstrong last week cut all official ties with Livestrong, the charity he founded 15 years ago while he was treated for testicular cancer.

On Nov. 4, he resigned from the organization’s board of directors; he had previously stepped down as the chairman of the board Oct. 17. He has distanced himself from the charity to try to protect it from any damage caused by his doping controversy, the new board chairman, Jeff Garvey, said in a statement.

“Lance Armstrong was instrumental in changing the way the world views people affected by cancer,” Garvey said. “His devotion to serving survivors is unparalleled, and for 15 years, he committed himself to that cause with all his heart.”

Garvey said that the Armstrong family had donated nearly $7 million to the foundation and that the organization under Armstrong had raised close to $500 million to serve cancer survivors.

Last month, the United States Anti-Doping Agency made public its evidence in its doping case against Armstrong, saying he had doped and encouraged his teammates to dope so they could help him win races. He was subsequently barred from Olympic sports for life and was stripped of all the cycling titles he won from August 1998 on.

Since then, Armstrong has spent several weeks in Hawaii, out of the public eye. On Saturday, though, he posted a photograph on Twitter showing him at home in Austin, Tex. He is lounging on a couch with his seven yellow Tour jerseys framed on the wall in the background.

In the post, he said, “Back in Austin and just layin’ around.” The photograph had more than 400,000 page views as of Monday evening, with many people posting negative comments on the page.

“Lance, you have no moral conscious and it’s obvious many of your followers don’t either,” said one person who went by the Twitter handle “irobot,” who also posted that Armstrong needed “professional help.”

A person posting under the name “Aumann” said: “An art thief enjoying all his da Vincis.”

Other people posted words of support, including many who said they still thought Armstrong was the top cyclist in history.

“TomShelton” said of Armstrong’s seven Tour titles, “You earned all 7 of them no matter what is being said about you!”

This article has been revised to reflect the following correction:

Correction: November 13, 2012

An earlier version of this article misstated Jeff Garvey’s estimate of the sum the Livestrong charity had raised to serve cancer survivors. It was close to $500 million, not close to $300 million.

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